" /> Cilazaprilat - CISMeF





Preferred Label : Cilazaprilat;

NCIt definition : The active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : WBL76FH528;

InChIKey : UVAUYSRYXACKSC-ULQDDVLXSA-N;

CAS number : 90139-06-3;

Chemical formula : C20H27N3O5;

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09/05/2025


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