" /> SIX3 wt Allele - CISMeF





Preferred Label : SIX3 wt Allele;

NCIt synonyms : SIX Homeobox 3 wt Allele; HPE2; Sine Oculis Homeobox, Drosophila, Homolog of, 3 Gene;

NCIt definition : Human SIX3 wild-type allele is located within 2p16-p21 and is approximately 4 kb in length. This allele, which encodes homeobox protein SIX3, plays a role in retinal development. Mutations in this gene are associated with holoprosencephaly 2.;

NCIt note : Six3 efficiently competes with Cdt1 directly to bind to geminin, which reveals how Six3 can promote cell proliferation without transcription. The transcription factor Six3 and the replication-initiation inhibitor geminin act antagonistically to control the balance between proliferation and differentiation during early vertebrate eye development. (Nature 2004;427: 745-9.);

GenBank Accession Number : AF092047; NM_005413;

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30/07/2025


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