NCIt synonyms : Zic Family Member 1 (Odd-Paired Homolog, Drosophila) wt Allele; ZIC; ZNF201;
NCIt definition : Human ZIC1 wild-type allele is located in the vicinity of 3q24 and is approximately
7 kb in length. This allele, which encodes zinc finger protein ZIC 1, plays roles
in regulation of transcription, development and differentiation of cerebellar granule
cells. Mutations in this gene are associated with Dandy-Walker malformation.;
NCIt note : A mouse model for Dandy-Walker Malformation (DWM) indicates that heterozygous deletion
of the region encompassing ZIC1 and ZIC 4 on 3q2 recapitulates the DWM phenotype.;
OMIM relation