NCIt definition : Tumor is clinically localized to the periprostatic area, but extends through the prostatic
capsule; the seminal vesicles may be involved.;
Alternative definition : NCI-GLOSS: A prostate cancer stage defined by the Jewett staging system. Stage C prostate
cancer is cancer that began in the prostate, has grown beyond the outer layer of the
prostate to nearby tissues, and may be found in the seminal vesicles (glands that
help produce semen). Stage C is divided into stages C1 and C2. In stage C1, the cancer
has grown outside the prostate but has not spread to lymph nodes or other places in
the body. In stage C2, the cancer has grown outside the prostate and blocks urine
flow from the bladder or through the ureters.;