Preferred Label : Recombinant Platelet-Derived Growth Factor;
NCIt synonyms : Platlet-Derived Growth Factor; rPDGF; Therapeutic Platlet-Derived Growth Factor;
NCIt definition : Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is
a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines
and released upon wounding to stimulate adjacent cell growth. PDGF can exist as antiparallel
disulfide-linked homodimers (PDGFA, PDGFB) or heterodimers (PDGFA/PDGFB) that could
bind to PDGF receptor and may elicit a variety of cellular responses. A and B homodimers
are implicated in transformation processes. (NCI);
Origin ID : C755;
UMLS CUI : C1515387;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
