NCIt definition : Human TGIF1 wild-type allele is located in the vicinity of 18p11.3 and is approximately
46 kb in length. This allele, which encodes homeobox protein TGIF1, may play a role
in regulation of TGF beta signalling (via the inhibition of SMAD2 phosphorylation).
Mutations in this gene are associated with holoprosencephaly 4.;