NCIt definition : The anhydrous form of argatroban, a synthetic derivative of L-arginine with antithrombotic
activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin.
This agent reversibly binds to the thrombin active site, thereby preventing the thrombin-dependent
reactions, which include the conversion of fibrinogen to fibrin; the activation of
factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban
is highly selective for thrombin and is able to inhibit the action of both free and
clot-associated thrombin. As a result, stabilization of blood clots occurs and coagulation
is inhibited.;
UNII : OCY3U280Y3;
InChIKey : KXNPVXPOPUZYGB-IOVMHBDKSA-N;
CAS number : 74863-84-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 74863-84-6
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