Topixantrone - CISMeF

Preferred Label : Topixantrone;

NCIt synonyms : Indazolo(4,3-gh)isoquinolin-6(2H)-one, 5-((2-(dimethylamino)ethyl)amino)-2-(2-((2-hydroxyethyl)amino)ethyl)-;

NCIt definition : A 9-aza-anthrapyrazole antineoplastic antibiotic. Topixantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Compared to other DNA intercalators, this agent shows minimal cardiotoxicity.;

UNII : R40RXC296C;

InChIKey : ZHAKYGFJVGCOAE-UHFFFAOYSA-N;

CAS number : 156090-18-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 156090-18-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BBR 3576;

Chemical formula : C21H26N6O2;

Details

Origin ID

C75124;

UMLS CUI

C2699968;

Automatic exact mappings (from CISMeF team)
- 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(dimethylamino)ethyl)amino)indazolo(4,3-gh)isoquinolin-6(2H)-one [MeSH concept]
- 2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(dimethylamino)ethyl)amino)indazolo(4,3-gh)isoquinolin-6(2H)-one [MeSH Supplementary Concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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