NCIt definition : A prodrug of the d-isomer of amphetamine, a non-catecholamine sympathomimetic amine
with central nervous system (CNS) stimulating activity. Upon administration, lisdexamphetamine
is converted to dextroamphetamine through cleavage of the lysine group. Dextroamphetamine
acts by facilitating the release of catecholamines, particularly noradrenaline and
dopamine, from its storage sites in nerve terminals in the CNS, and inhibits their
uptake within the mesocorticolimbic system, a major component of the brain reward
system, resulting in measurable behavioral changes such as euphoria, mental alertness
and excitement and appetite suppression. As a CNS stimulant, this agent may increase
blood pressure.;