Propacetamol - CISMeF

Preferred Label : Propacetamol;

NCIt definition : A water-soluble para-aminophenol derivative and ester prodrug of acetaminophen in which acetaminophen is bound to the carboxylic acid diethylglycine, with analgesic and antipyretic activities. Upon intravenous administration, propacetamol is hydrolyzed by plasma esterases into its active form acetaminophen. Although the exact mechanism of action has yet to be fully elucidated despite its widespread use, acetaminophen enters the central nervous system and acts centrally. This agent binds to cyclooxygenase (COX) and prevents the metabolism of arachidonic acid to prostaglandin. A reduction in prostaglandin formation relieves pain and reduces fever. Acetaminophen may also act centrally on cannabinoid receptors and on N-methyl-D-aspartate (NMDA) receptors.;

UNII : 5CHW4JMR82;

InChIKey : QTGAJCQTLIRCFL-UHFFFAOYSA-N;

CAS number : 66532-85-2;

Chemical formula : C14H20N2O3;

Details

Origin ID

C75081;

UMLS CUI

C0084186;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 4-acetamidophenyl n,n-diethylaminoacetate monohydrochloride [Substance BNPC]
- propacetamol [ATC Code]
- propacetamol [MeSH concept]
- propacetamol [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- 4-acetamidophenyl n,n-diethylaminoacetate monohydrochloride [Substance BNPC]
- propacetamol [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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