Alacepril - CISMeF

Preferred Label : Alacepril;

NCIt definition : A long-acting, sulfhydryl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, alacepril is rapidly metabolized to captopril; captopril competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Captopril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : X39TL7JDPF;

InChIKey : FHHHOYXPRDYHEZ-COXVUDFISA-N;

CAS number : 74258-86-9;

Chemical formula : C20H26N2O5S;

Details

Origin ID

C75021;

UMLS CUI

C0051050;

Automatic exact mappings (from CISMeF team)
- Alacepril [ICHI extension code]
Currated CISMeF NLP mapping
- Alacepril [ICD-11 Extension code]
- alacepril [MeSH concept]
- alacepril [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Alacepril [ICD-11 Extension code]
- alacepril [MeSH concept]
- alacepril [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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