Preferred Label : Alpha-Tocopherol;
NCIt synonyms : 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol;
NCIt related terms : .ALPHA.-TOCOPHEROL; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol;
NCIt definition : The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin
E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol
neutralizes free radicals, thereby protecting tissues and organs from oxidative damage.
Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation
and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting
the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein
kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression
of various genes, plays a key role in neurological function, inhibits platelet aggregation
and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol
is the most biologically active form and is the form that is preferentially absorbed
and retained in the body.;
Alternative definition : CRCH: Tocopherol with three methyl groups on its chromanol ring.;
UNII : H4N855PNZ1;
CAS number : 59-02-9;
Unit used : mg;
Chemical formula : C29H50O2;
NCI Metathesaurus CUI : CL938214;
ChEBI ID : CHEBI:18145;
Origin ID : C74960;
UMLS CUI : C0969677;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
