Preferred Label : Heat Shock Protein Inhibitor;
NCIt synonyms : Hsp Inhibitor;
NCIt definition : Any agent that inhibits functions of heat shock proteins (Hsp). Hsps are a group of
homodimeric molecular chaperones that interact with a diverse group of proteins, assisting
in their folding and in the elimination of any misfolded or damaged molecules. Although
transiently expressed during cell cycle in normal cells, Hsps are constitutively elevated
in various types of cancer which raises the apoptosis threshold of these tumor cells
and provides protection against cytotoxic agents. Hsp inhibitors may destabilize,
and facilitate degradation of proto-oncoproteins leading to reversal of apoptosis
regulation and cell death.;
Origin ID : C74526;
UMLS CUI : C2697571;
Semantic type(s)
concept_is_in_subset