NCIt definition : An orally bioavailable dihydro-benzofuran-carboxamide and selective serotonin (5-HT4)
receptor agonist, with gastrointestinal (GI) prokinetic activity. Upon oral administration,
prucalopride specifically targets, binds to and stimulates the 5-HT4 receptor. This
alters colonic motility patterns and stimulates colonic mass movements. This may normalize
bowel movements and may relief chronic constipation. In addition, by increasing esophageal
and gastric motility, prucalopride may also provide relief for aspiration-associated
symptoms.;