NCIt definition : A radioimmunoconjugate consisting of the murine IgG1 monoclonal antibody BW250/183
labeled with yttrium Y 90 with potential radioimmunotherapeutic activity. Yttrium
Y 90 anti-CD66 monoclonal antibody BW 250/183 binds to a 95 kD nonspecific cross-reacting
antigen (CD66b or NCA-95) on granulocytes, selectively delivering a cytotoxic dose
of Y 90 beta radiation to CD66b-expressing cells. CD66b, a member of the carcinoembryonic
antigen (CEA) family with an unknown function, appears early in the differentiation
of granulopoietic cells and is expressed on the cell surface of almost all human granulocytes
and their more mature precursors.;
See also inter- (CISMeF)