NCIt definition : A peptide vaccine containing an HLA-A*2402-restricted epitope of vascular endothelial
growth factor receptor (VEGFR) 2 with potential immunostimulatory and antineoplastic
activities. Upon administration, VEGFR2-169 peptide vaccine may stimulate a cytotoxic
T lymphocyte (CTL) response against VEGFR2-expressing tumor cells. VEGFR2, a receptor
tyrosine kinase, is overexpressed by a variety of tumor types; overexpression is associated
with tumor cell proliferation and tumor angiogenesis. HLA-A*2402 is an MHC class I
molecule that presents antigenic peptides to CD8 T cells; epitope design restricted
to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide
immunogenicity.;
UNII : S68632MB2G;
InChIKey : ZAJHBCDPAUKEPU-GIKXZWSFSA-N;
CAS number : 673478-49-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 673478-49-4
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