Preferred Label : Vaccinia Virus DD-CDSR;
NCIt synonyms : Vaccinia Virus (vvDD-CDSR); vvDD-CDSR; Vaccinia virus DD-CDSR Vaccine;
NCIt definition : A highly tumor-selective vaccinia virus (vv) with an engineered double deletion (DD)
of the thymidine kinase (tk) and vaccinia growth factor genes and additions of both
a cytosine deaminase (CD) gene and a somatostatin receptor (SR) gene with potential
oncolytic viral activity. The tk and vaccinia growth factor gene deletions in intratumorally
administered vaccinia virus (vvDD-CDSR) help to restrict its replication and cytolytic
activity to tumor cells with large nucleotide pools and tumor cells with activation
of the EGFR-Ras pathway. Addition of the CD gene to the viral genome allows control
of oncolytic viral infection through the administration of the prodrug 5-fluorocytosine
(5-FC), converted by CD to the antimetabolite 5-fluorouracil (5-FU) in cells infected
with this agent. Addition of the SR gene allows anatomical localization of vaccinia
virus (vvDD-CDSR) through the use of octreotide scintigraphy.;
NCI Metathesaurus CUI : CL384004;
Origin ID : C74089;
UMLS CUI : C2700142;
Semantic type(s)
- concept_is_in_subset
