Preferred Label : Topical Gemcitabine Hydrochloride;
NCIt definition : A topical preparation of gemcitabine hydrochloride with antineoplastic activity. Gemcitabine,
an analogue of the antimetabolite nucleoside deoxycytidine, is converted intracellularly
to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP).
dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool
available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand
termination and apoptosis.;
NCI Metathesaurus CUI : CL383495;
Origin ID : C74085;
UMLS CUI : C2348805;
Semantic type(s)
- concept_is_in_subset
