NCIt definition : A synthetic oligonucleotide containing unmethylated CpG dinucleotides with potential
immunopotentiating activity. Mimicking unmethylated CpG sequences in bacterial DNA,
TLR9 agonist IMO-2055 binds to and activates intracellular Toll-like receptors (TLR)
9 in monocytes/macrophages, plasmacytoid dendritic cells (DCs) and B cells, initiating
immune signaling pathways and activating B cells and DCs and inducing T-helper cell
cytokine production. TLR9 is a member of the TLR family, which plays a fundamental
role in pathogen recognition and activation of innate immunity.;
Semantic type(s)