PNP-Expressing Ovine Atadenovirus FP253

Preferred Label : PNP-Expressing Ovine Atadenovirus FP253;

NCIt synonyms : PNP-Expressing Atadenovirus FP253;

NCIt definition : An ovine atadenovirus encoding E. coli purine nucleoside phosphorylase (PNP) with prodrug activating activity. Under the control of a prostate-directed promoter, PNP-expressing atadenovirus vaccine FP253 expresses PNP in prostate tissue only after intraprostatic administration; this enzyme catalyzes systemically administered fludarabine prodrug into the active agent, 2-fluoroadenine. Localized prodrug activation provides prostate-targeted chemotherapy, potentially reducing systemic side effects.;

Molecule name : FP253-GDEPT; FP253;

NCI Metathesaurus CUI : CL383539;

Details

Origin ID

C74074;

UMLS CUI

C2347428;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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