Preferred Label : PEP-3-KLH Conjugate Vaccine;
NCIt synonyms : PEP-3-KLH;
NCIt definition : A cancer vaccine consisting of PEP-3, a synthetic peptide encompassing a tumor-specific
mutated segment of the epidermal growth factor receptor type vIII (EGFRvIII), conjugated
to the naturally-occurring immunoadjuvant keyhole limpet hemocyanin (KLH) with potential
immunostimulating and antineoplastic activities. Upon administration, PEP-3-KLH conjugate
vaccine may induce a cytotoxic immune response against tumor cells that overexpress
EGFRvIII; this antitumoral immune response may involve antibody-dependent cellular
cytotoxicity (ADCC).;
Origin ID : C74070;
UMLS CUI : C1541477;
Semantic type(s)
- concept_is_in_subset
- has_target
