Parathyroid Hormone-Related Protein (1-36)

Preferred Label : Parathyroid Hormone-Related Protein (1-36);

NCIt synonyms : PTHrP (1-36); Parathyroid Hormone-Related Protein 1-36 Peptide;

NCIt definition : A recombinant form of a mature, N-terminal secretory peptide derived from a parathyroid hormone-related protein (PTHrP) preprohormone through posttranslational endoproteolytic processing with vasodilating, myorelaxant, and parathyroid hormone (PTH)-like calciotropic activities. Expressed throughout the cardiovascular system, parathyroid hormone-related protein (1-36) [PTHrP (1-36)] was first identified as the PTH-like hypercalcemic factor of humoral hypercalcemia of malignancy; however, its sequence differs significantly from that of PTH (1-34) although both proteins share the same N-terminal end which accounts for the calciotropic activity. Both PTHrP (1-36) and PTH (1-34) bind to the type 1 parathyroid hormone receptor (PTH1R), a specific seven-transmembrane-helix-containing G protein-coupled receptor mainly located in bone and kidney cells.;

Details

Origin ID

C74068;

UMLS CUI

C0213895;

Automatic exact mappings (from CISMeF team)
- parathyroid hormone-related peptide (1-36) [MeSH concept]
- parathyroid hormone-related peptide (1-36) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- parathyroid hormone-related peptide (1-36) [MeSH concept]
- parathyroid hormone-related peptide (1-36) [MeSH Supplementary Concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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