Preferred Label : Mixed Bacteria Vaccine;
NCIt synonyms : Coley's Toxin; MBV;
NCIt definition : A cancer vaccine containing a mixture of killed bacteria with potential immunostimulatory
and antineoplastic activities. Mixed bacteria vaccine (MBV or Coley's toxins) consists
of a pyrogenic bacterial lysate derived from Serratia marcescens and Streptococcus
pyogenes; the active components in the lysate may be lipopolysaccharide (LPS), a component
of the Gram-negative bacterial cell wall of Serratia, and streptokinase, an enzyme
produced by Streptococcus pyogenes. LPS has been shown to stimulate the host humoral
immune response and induce the release of various antitumor cytokines such as tumor
necrosis factor (TNF) and interleukin-12 (IL-12).;
NCI Metathesaurus CUI : CL383537;
Origin ID : C74063;
UMLS CUI : C2347170;
Semantic type(s)
- concept_is_in_subset
