Preferred Label : LY6K/VEGFR1/VEGFR2 Multipeptide Vaccine;
NCIt synonyms : LY6K VEGFR1 VEGFR2 Multipeptide Vaccine;
NCIt definition : A multipeptide vaccine consisting of peptides derived from lymphocyte antigen 6 complex
locus K (LY6K) and type I and II vascular endothelial growth factor receptors (VEGFRs)
with potential antineoplastic activity. Upon administration, LY6K/VEGFR1/VEGFR2 multipeptide
vaccine may elicit an antitumor cytotoxic T-lymphocyte (CTL) immune response against
LY6K-expressing tumor cells and/or VEGFR-expressing vascular endothelial cells involved
in tumor angiogenesis. LY6K is a tumor-associated antigen (TAA) that occurs singly
in glycosylphosphatidyl-inositol (GPI)-linked cell-surface glycoproteins or as three-fold
repeated domain in the urokinase-type plasminogen activator receptor; VEGFRs are cell
surface receptors that stimulate endothelial cell proliferation, invasion, angiogenesis,
and vasculogenesis upon ligand binding and receptor activation.;
NCI Metathesaurus CUI : CL383456;
Origin ID : C74056;
UMLS CUI : C2346629;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
