Preferred Label : Idiotype-Pulsed Autologous Dendritic Cell Vaccine APC8020;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with
tumor-derived clonal immunoglobulin (Ig) with potential immunostimulatory and antineoplastic
activities. Upon administration, idiotype-pulsed autologous dendritic cell vaccine
APC8020, containing idiotype (Id) protein structures that can be recognized by antibodies
and by CD41 T lymphocytes and CD81 T lymphocytes, may stimulate antitumoral cytotoxic
T lymphocyte (CTL) and antibody responses against Id-expressing tumor cells. The Id
represents the unique antigenic determinants in the variable regions of the clonal
Ig.;
Drug name : Mylovenge;
Molecule name : APC8020;
NCI Metathesaurus CUI : CL383479;
Origin ID : C74042;
UMLS CUI : C2346463;
Semantic type(s)
- concept_is_in_subset
