Preferred Label : huBC1-huIL12 Fusion Protein AS1409;
NCIt definition : An immunoconjugate consisting of the anti-tumor cytokine interleukin-12 (IL-12) fused
to the tumor-targeting antibody BC1 with potential immunostimulatory and antineoplastic
activities. The antibody moiety of huBC1-huIL12 fusion protein AS1409 binds to the
human fibronectin splice variant ED-B, delivering IL-12 directly to the tumor vasculature;
tumor vasculature-targeted IL-12 initiates localized immune cascade responses and
exhibits cytotoxic and anti-angiogenic activity while minimizing the systemic side
effects of IL-12. The human fibronectin splice variant ED-B is over-expressed in the
extracellular matrix and blood vessels of tumor tissues.;
Molecule name : AS1409;
NCI Metathesaurus CUI : CL383540;
Origin ID : C74041;
UMLS CUI : C2346560;
Semantic type(s)
- concept_is_in_subset
