Preferred Label : HLA-A*2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt synonyms : HLA-A 2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt definition : A cancer vacine containing four HLA-A*2402-restricted peptide epitopes with potential
immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived
from: URLC10 (up-regulated lung cancer 10), TTK (TTK protein kinase), and VEGFRs (vascular
endothelial growth factor receptors) 1 and 2. Upon administration, URLC10-TTK-KOC1-VEGFR1-VEGFR2
multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against
tumor cells expressing URLC10, TTK, VEGFR 1 and 2 peptides, resulting in cell lysis
and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic
peptides to CD8 T cells; epitope design restricted to epitopes that bind most efficiently
to HLA-A*2402 may improve antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL383552;
Origin ID : C74039;
UMLS CUI : C2348920;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
