Preferred Label : Diclofenac Sodium Gel;
NCIt related terms : Voltaren gel;
NCIt definition : A gel formulation of the sodium salt of diclofenac, a nonsteroidal benzeneacetic acid
derivative with analgesic, antipyretic and anti-inflammatory activities. Diclofenac
binds to and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking
the conversion of arachidonic acid (AA) to pro-inflammatory prostaglandins. This agent
may also inhibit lipoxygenases, resulting in the inhibition of pro-inflammatory leukotriene
synthesis from AA.;
Alternative definition : NCI-GLOSS: The gel form of a drug that is used to treat the symptoms of rheumatoid
arthritis and is being studied in the prevention and treatment of some types of skin
cancer. It blocks substances that cause inflammation and pain. It may also prevent
the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase
inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis
agent.;
Drug name : Solaraze;
Codes from synonyms : CDR0000617663; CDR0000617662;
Origin ID : C74024;
UMLS CUI : C2348252;
Semantic type(s)
- concept_is_in_subset
