Preferred Label : Autologous Dendritic Cell-Adenovirus CCL21 Vaccine;
NCIt definition : A cancer vaccine comprised of autologous dendritic cells (DCs) that have been transduced
ex vivo with an adenoviral vector containing the CCL21 gene with potential immunostimulatory
and antineoplastic activities. Upon intratumoral administration, autologous dendritic
cell-adenovirus CCL21 vaccine expresses the chemokine CCL21, which may induce an antitumoral
cytotoxic immune response in the tumor microenvironment. CCL21 [chemokine (C-C motif)
ligand 21] has been shown to attract antigen presenting cells (APCs), like leukocytes
and DCs, and natural killer (NK) cells and their T-cell effectors to induce a cytotoxic
immune response.;
NCI Metathesaurus CUI : CL383468;
Origin ID : C74015;
UMLS CUI : C2346882;
Semantic type(s)
- concept_is_in_subset
