Carotuximab - CISMeF

Preferred Label : Carotuximab;

NCIt synonyms : Anti-Endoglin Chimeric Monoclonal Antibody TRC105;

NCIt definition : A human/murine chimeric monoclonal antibody directed against endoglin (CD105) with potential antiangiogenic and antineoplastic activities. Carotuximab binds to endoglin, which may result in inhibition of tumor angiogenesis and decreased tumor cell proliferation. The glycoprotein endoglin is a transforming growth factor beta-1 (TGF beta-1) accessory receptor that is highly expressed on tumor vessel endothelial cells and appears to be essential for angiogenesis.;

UNII : YB2EWE6139;

CAS number : 1268714-50-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1268714-50-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TRC-105; TRC 105;

Details

Origin ID

C74010;

UMLS CUI

C4727597;

Automatic exact mappings (from CISMeF team)
- carotuximab [MeSH concept]
Currated CISMeF NLP mapping
- carotuximab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TRC105 [MeSH concept]
- carotuximab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Endoglin [NCIt concept]

Keyword's position in hierarchy(ies) :

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