Preferred Label : CD40 Agonist Monoclonal Antibody CP-870,893;
Obsolete resource : true;
NCIt synonyms : Anti-CD40 Monoclonal Antibody CP-870 893;
NCIt definition : A fully human monoclonal antibody (mAb) agonist of the cell surface receptor CD40
with potential immunostimulatory and antineoplastic activities. Similar to the CD40
ligand (CD40L or CD154), CD40 agonist monoclonal antibody CP-870,893 binds to CD40
on a variety of immune cell types, triggering the cellular proliferation and activation
of antigen-presenting cells (APCs), activating B cells and T cells, and enhancing
the immune response; in addition, this agent may activate CD40 present on the surfaces
of some solid tumor cells, resulting in apoptosis and decreased tumor growth. CD40,
a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on
various immune cells, many B-cell malignancies, and some solid tumors, mediating both
indirect tumor cell killing through the activation of the immune system and direct
tumor cell apoptosis.;
NCIt note : See 'Selicrelumab(C119740)';
Concept status : Retired_Concept;
Molecule name : CP-870,893;
Origin ID : C74008;
UMLS CUI : C1869412;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
