NCIt synonyms : Immunoglobulin, Anti-(Human CD Antigen CD37) (Synthetic Human-Mus Musculus Fragment
TRU-016), Dimer; Anti-CD37 Single-Chain Polypeptide TRU-016;
NCIt definition : A recombinant single-chain polypeptide engineered to exhibit the full binding and
activity of an anti-CD37 monoclonal antibody with potential immunostimulatory and
antineoplastic activities. Otlertuzumab binds to CD37 on B-cells, which may result
in antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis. CD37 is a transmembrane
glycoprotein expressed at high-levels on B cells and to a lesser extent on T cells
and myeloid cells. This agent may have a longer half-life in vivo than conventional
monoclonal antibodies.;