Preferred Label : Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1);
NCIt synonyms : A-dmDT390-bisFv(UCHT1); Anti-CD3 Immunotoxin A-dmDT390-bisFv UCHT1;
NCIt related terms : RESIMMUNE;
NCIt definition : A bivalent recombinant fusion protein immunotoxin derived from the anti-CD3 monoclonal
antibody UCHT1 with potential antineoplastic activity. Anti-CD3 immunotoxin A-dmDT390-bisFv(UCHT1)
consists of 1-390 amino acid residues of chain A diphtheria toxin (DT) joined via
a spacer to the Fv fragment of UCHT1, which is connected to a second UCHT1 Fv fragment
via a disulfide bond (hence the bisFv designation); the addition of the second Fv
fragment overcomes the steric hindrance of immunotoxin binding due to the large N-terminal
DT domain. Once inside target T cells, the DT moiety catalyzes the transfer of the
ADP-ribose moiety of NAD to diphthamide, a posttranslationally modified histidine
residue found in elongation factor 2 (EF-2); inactivation of EF-2, disruption of polypeptide
chain elongation, and cell death ensue. CD3 is a complex of five cell-surface polypeptides
associated with the T cell receptor (TCR) complex.;
UNII : P7MQ9ZOQ82;
CAS number : 1470038-56-2;
Drug name : Resimmune;
NCI Metathesaurus CUI : CL383887;
Origin ID : C74004;
UMLS CUI : C2346803;
Semantic type(s)
- concept_is_in_subset
