NCIt definition : An ammonium salt with potential antiangiogenic and antitumor activities. Tetrathiomolybdate
has been found to deplete systemic copper reserves through an unknown mechanism. This
agent has been shown to inhibit the activities of cuproenzymes, including superoxide
dismutase 1 (SOD1) and cytochrome c oxidase (COX), which may contribute to its antiangiogenic
and antitumor effects.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of many types of cancer. Ammonium
tetrathiomolybdate removes extra copper from the body. Removing the copper may prevent
the growth of new blood vessels that tumors need to grow and may kill cancer cells.
Ammonium tetrathiomolybdate is a type of chelating agent and a type of antiangiogenesis
agent.;