Preferred Label : AML mRNA Positive Lysate Loaded Autologous Dendritic Cell Vaccine;
NCIt synonyms : Acute Myelogenous Leukemia mRNA Plus Lysate Loaded Autologous Dendritic Cell Vaccine;
NCIt definition : A cancer vaccine consisting of autologous dendritic cells loaded with separate preparations
of acute myelogenous leukemia (AML) cell lysate and AML-specific messenger RNA (mRNA)
with potential immunostimulatory and antineoplastic activities. Upon administration,
AML mRNA plus lysate loaded autologous dendritic cell vaccine may elicit a potent
cytotoxic T-cell (CTL) response against AML cells, resulting in tumor cell death.
Autologous dendritic cells doubly-loaded with AML cell lysate and AML-specific mRNA
may elicit superior primary, recall, and effector lytic immune responses compared
to autologous dendritic cells loaded with tumor lysate or tumor mRNA alone.;
NCI Metathesaurus CUI : CL383547;
Origin ID : C74000;
UMLS CUI : C2348851;
Semantic type(s)
- concept_is_in_subset
