Revaprazan Hydrochloride

Preferred Label : Revaprazan Hydrochloride;

NCIt definition : The hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. Revaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H /K ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H ions into the gastric lumen, the final step in gastric acid production.;

UNII : 4DQ6T10R64;

InChIKey : MALPZYQJEDBIAK-UHFFFAOYSA-N;

CAS number : 178307-42-1;

Chemical formula : C22H23FN4.HCl;

Details

Origin ID

C73839;

UMLS CUI

C2347960;

Automatic exact mappings (from CISMeF team)
- YH 1885 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- revaprazan hydrochloride [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- revaprazan hydrochloride [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Revaprazan [NCIt concept]
is_salt_form_of
- Revaprazan [NCIt concept]

Keyword's position in hierarchy(ies) :

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