NCIt definition : The hydrochloride salt form of a lipophilic, weak base with potassium-competitive
acid blocking (P-CAB) activity. Revaprazan concentrates highly in the gastric parietal
cell canaliculus and on entering this acidic environment is instantly protonated and
binds competitively and reversibly to the potassium binding site of the proton pump
hydrogen-potassium adenosine triphosphatase (H /K ATPase), thereby inhibiting the
pump's activity and the parietal cell secretion of H ions into the gastric lumen,
the final step in gastric acid production.;