Preferred Label : Parecoxib Sodium;
NCIt synonyms : Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-, Sodium Salt;
NCIt definition : A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the
cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID)
valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous
or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases
to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2.
This prevents the conversion of arachidonic acid into prostaglandins, which are involved
in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1
at therapeutic concentrations and, therefore, does not interfere with blood coagulation.;
UNII : EB87433V6F;
InChIKey : HQPVVKXJNZEAFW-UHFFFAOYSA-M;
CAS number : 198470-85-8;
Drug name : Dynastat;
Chemical formula : C19H17N2O4S.Na;
Origin ID : C73831;
UMLS CUI : C0915144;
Semantic type(s)
- concept_is_in_subset
