Nasopharyngeal Non-Keratinizing Carcinoma

Preferred Label : Nasopharyngeal Non-Keratinizing Carcinoma;

NCIt synonyms : NK-NPC; Nasopharyngeal Nonkeratinizing Carcinoma;

NCIt related terms : Nasopharyngeal Throat Nonkeratinizing Cancer; EBV positive nasopharyngeal carcinoma;

NCIt definition : A nasopharyngeal carcinoma characterized by the lack of keratinization and the presence of a dense lymphoplasmacytic infiltrate. It is subdivided into undifferentiated and differentiated types, based on the cytologic features of the malignant cells. The undifferentiated type is characterized by the presence of cells with large vesicular nuclei with prominent nucleoli and a syncytial pattern of growth. The differentiated type is characterized by the presence of smaller cells and cellular stratification reminiscent of transitional cell carcinoma. While morphologically distinct, both types have similar clinical presentation and prognosis.;

Neoplastic status : Malignant;

Details

Origin ID

C7373;

UMLS CUI

C1334926;

Currated CISMeF NLP mapping
- Nonkeratinising carcinoma of nasopharynx [MedDRA Preferred Term]
- Nonkeratinizing carcinoma of nasopharynx [MedDRA LLT]
Disease excludes abnormal cell
- Keratinizing Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Headache [NCIt concept]
- Nasal Obstruction [NCIt concept]
- Neck Mass [NCIt concept]
- Rhinorrhea [NCIt concept]
- Tinnitus [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
Manual BTNT mappings - CISMeF
- undifferentiated keratinizing nasopharyngeal carcinoma [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Keratin Pearls Formation [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Squamous Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
disease_has_associated_disease
- EBV Infection [NCIt concept]
- Infectious Disorder [NCIt concept]
- Viral Infection [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Lymphoplasmacytic Infiltrate [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
- Squamous Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Nasopharynx Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
- Throat [NCIt concept]
disease_mapped_to_gene
- HLA-A Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 11q [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 14q [NCIt concept]
- Loss of Chromosome 16q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
- Loss of Chromosome 9p [NCIt concept]
- Loss of Chromosome 9q [NCIt concept]
disease_may_have_molecular_abnormality
- CDKN2A Gene Inactivation [NCIt concept]
- EGFR Protein Overexpression [NCIt concept]
- RASSF1A Gene Inactivation [NCIt concept]

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