Nasopharyngeal Non-Keratinizing Carcinoma

Preferred Label : Nasopharyngeal Non-Keratinizing Carcinoma;

NCIt synonyms : NK-NPC; Nasopharyngeal Nonkeratinizing Carcinoma;

NCIt related terms : Nasopharyngeal Throat Nonkeratinizing Cancer;

NCIt definition : A nasopharyngeal carcinoma characterized by the lack of keratinization and the presence of a dense lymphoplasmacytic infiltrate. The vast majority of cases are associated with Epstein-Barr virus infection. It is subdivided into differentiated and undifferentiated types, based on the cytologic features of the malignant cells. The differentiated type (type II) is characterized by the presence of smaller cells and cellular stratification reminiscent of transitional cell carcinoma. The undifferentiated type (type III) is characterized by the presence of cells with large vesicular nuclei with prominent nucleoli and a syncytial pattern of growth. While morphologically distinct, both types have similar clinical presentation and prognosis.;

Neoplastic status : Malignant;

Détails

Origin ID

C7373;

UMLS CUI

C1334926;

Currated CISMeF NLP mapping
- Nonkeratinising carcinoma of nasopharynx [MedDRA Preferred Term]
- Nonkeratinizing carcinoma of nasopharynx [MedDRA LLT]
Disease excludes abnormal cell
- Keratinizing Malignant Squamous Cell [NCIt concept]
- Malignant Stromal Cell [NCIt concept]
- Neoplastic Glandular Cell [NCIt concept]
- Neoplastic Smooth Muscle Cell [NCIt concept]
Disease may have findings
- Epstein-Barr Virus Positive [NCIt concept]
- Headache [NCIt concept]
- Nasal Obstruction [NCIt concept]
- Neck Mass [NCIt concept]
- Rhinorrhea [NCIt concept]
- Tinnitus [NCIt concept]
- Weight Loss [NCIt concept]
Has associated anatomic sites
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
Manual BTNT mappings - CISMeF
- undifferentiated keratinizing nasopharyngeal carcinoma [Disease (Nov.)]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Keratin Pearl Formation [NCIt concept]
- Keratin Present [NCIt concept]
- Mixed Neoplastic Glandular and Squamous Cell Population [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Epithelial Cell [NCIt concept]
- Malignant Squamous Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Epithelial Cell [NCIt concept]
- Neoplastic Squamous Cell [NCIt concept]
- Non-Keratinizing Malignant Squamous Cell [NCIt concept]
disease_has_finding
- Carcinomatous Component Present [NCIt concept]
- Epithelial Component Present [NCIt concept]
- Lymphoplasmacytic Infiltrate [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_cell_origin
- Epithelial Cell [NCIt concept]
disease_has_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
- Mucosa [NCIt concept]
- Nasopharynx Epithelium [NCIt concept]
disease_has_primary_anatomic_site
- Head and Neck [NCIt concept]
- Nasopharynx [NCIt concept]
- Neck [NCIt concept]
- Pharynx [NCIt concept]
- Throat [NCIt concept]
disease_mapped_to_gene
- HLA-A Gene [NCIt concept]
disease_may_have_associated_disease
- EBV Infection [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 11q [NCIt concept]
- Loss of Chromosome 13q [NCIt concept]
- Loss of Chromosome 14q [NCIt concept]
- Loss of Chromosome 16q [NCIt concept]
- Loss of Chromosome 3p [NCIt concept]
- Loss of Chromosome 9p [NCIt concept]
- Loss of Chromosome 9q [NCIt concept]
disease_may_have_molecular_abnormality
- CDKN2A Gene Inactivation [NCIt concept]
- EGFR Protein Overexpression [NCIt concept]
- Inactivating RASSF1 Gene Mutation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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