Preferred Label : Pertussis Toxin;
NCIt definition : A class of biologically active protein toxins expressed by Bordetella pertussis, which
causes the symptoms of whooping cough. Following bacterial expression or administration
of pertussis toxin (PT), the B component of the toxin binds to a cell surface receptor.
The entire toxin is internalized by the cell, it is transported to the endosome and
then undergoes retrograde transport to the endoplasmic reticulum (ER). During transport
the A component undergoes a conformational change that activates its enzymatic activity.
The active A component catalyzes the ADP-ribosylation of Gi alpha subunits of heterotrimeric
G proteins, which inhibits G protein-coupled receptor signaling and adenylate cyclase
activity. This leads to increased concentrations of cyclic AMP (cAMP), which dysregulates
insulin production, chemokine synthesis, and the innate immune response. PT may have
various therapeutic effects, including antihypertensive, antiviral, and autoimmune
inhibition, but the mechanism(s) of action by which PT exerts its therapeutic activities
has not yet been fully elucidated.;
Origin ID : C736;
UMLS CUI : C0020731;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
