Preferred Label : Mebeverine Hydrochloride;
NCIt synonyms : Benzoic Acid, 3,4-Dimethoxy-, 4-(ethyl(2-(4-methoxyphenyl)-1-methylethyl)amino)butyl
Ester, Hydrochloride; Mebeverine HCl; 4-(Ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl Veratrate Hydrochloride;
NCIt definition : The hydrochloride salt form of mebeverine, an orally bioavailable reserpine derivative
and anticholinergic agent, with spasmolytic activity. Upon administration, mebeverine
targets, binds to and blocks the muscarinic receptors on smooth muscle cells in target
tissues, such as the gastrointestinal (GI) tract, uterus, gallbladder and bladder.
This prevents smooth muscle contraction and relaxes smooth muscle. Additionally, this
may prevent spasms, ease pain and cramps in the GI tract and improve incontinence.
In addition, mebeverine stabilizes excitable membranes by decreasing the permeability
of ion channels and preventing intracellular calcium accumulation. This agent also
blocks noradrenaline reuptake by sympathetic nerve endings and exerts a local anesthetic
effect.;
UNII : 15VZ5AL4JN;
InChIKey : PLGQWYOULXPJRE-UHFFFAOYSA-N;
CAS number : 2753-45-9;
Drug name : Colofac;
Chemical formula : C25H35NO5.HCl;
Origin ID : C73596;
UMLS CUI : C0771014;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
