" /> NKX2-1 wt Allele - CISMeF





Preferred Label : NKX2-1 wt Allele;

NCIt synonyms : TEBP; TTF1; NK-2; NKX2.1; TTF-1; BHC; BCH; NK2 Homeobox 1 wt Allele; NKX2A; TITF1;

NCIt definition : Human NKX2-1 wild-type allele is located in the vicinity of 14q13 and is approximately 4 kb in length. This allele, which encodes thyroid transcription factor 1 protein, is involved in the modulation of transcription for thyroid specific genes and may play a role in lung development. Mutations in the gene are associated with hypothyroidism, neonatal respiratory distress, and both benign hereditary chorea and choreoathetosis.;

NCIt note : The NKX2-1 gene is a candidate proto-oncogene involved in a significant fraction of lung adenocarcinomas.;

GenBank Accession Number : NM_003317;

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31/07/2025


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