Moxidectin - CISMeF

Preferred Label : Moxidectin;

NCIt definition : A macrocyclic lactone derived from Streptomyces cyanogriseus with antiparasitic activity. Upon administration, moxidectin may bind to glutamate-gated chloride channels (GluCl), gamma-aminobutyric acid (GABA) receptors and/or ATP-binding cassette (ABC) transporters expressed on nematode neurons and pharyngeal muscle cells. As a result, neurons or muscle cells remain at either hyperpolarization or depolarization state, thereby resulting in muscle paralysis. Moxidectin reduces the motility and fertility of the parasite and its excretion of immunomodulatory proteins, and inhibits the release of microfilariae.;

UNII : NGU5H31YO9;

InChIKey : YZBLFMPOMVTDJY-LSGXYNIPSA-N;

CAS number : 113507-06-5;

Chemical formula : C37H53NO8;

Details

Origin ID

C73264;

UMLS CUI

C0163557;

Automatic exact mappings (from CISMeF team)
- Moxidectin [ICD-11 Extension code]
- moxidectin [ATC Code]
Currated CISMeF NLP mapping
- Moxidectin (substance) [SNOMED CT concept]
- milbemycin b [Substance BNPC]
- moxidectin [MeSH concept]
- moxidectin [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Moxidectin (substance) [SNOMED CT concept]
- Product containing moxidectin (medicinal product) [SNOMED CT concept]
- moxidectin [ATC Code]
- moxidectin [MeSH Supplementary Concept]
- moxidectin [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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