Galocitabine - CISMeF

Preferred Label : Galocitabine;

NCIt definition : An orally available 5-fluorouracil (5-FU) prodrug with potential antineoplastic activity. Upon administration, galocitabine is converted into 5'-deoxy-5-fluorocytidine, 5'-deoxy-fluorouridine, and 5-FU. 5-FU is further metabolized into other cytotoxic metabolites that interfere with RNA and DNA synthesis via inhibition of thymidylate synthase. As a result, this agent eventually inhibits tumor cell growth.;

UNII : X9788XI79O;

InChIKey : TVYPSLDUBVTDIS-FUOMVGGVSA-N;

CAS number : 124012-42-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 124012-42-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : Ro 09-1390;

Chemical formula : C19H22FN3O8;

Details

Origin ID

C73254;

UMLS CUI

C2348731;

Automatic exact mappings (from CISMeF team)
- Ro 09-1390 [MeSH concept]
- Ro 09-1390 [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- galocitabine [MeSH concept]
- galocitabine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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