Retelliptine - CISMeF

Preferred Label : Retelliptine;

NCIt synonyms : 1-((3-(Diethylamino)propyl)amino)-5,11-dimethyl-9-methoxy-6H-pyrido(4,3-b)carbazole;

NCIt definition : An ellipticine derivative and topoisomerase II inhibitor with antineoplastic activity. Retelliptine intercalates with DNA and inhibits topoisomerase II during DNA replication. In addition, this agent appears to induce cell cycle arrest at G2/M phase and apoptosis mediated through the Fas/Fas ligand death receptor and the mitochondrial pathway.;

UNII : SZ0F94M68J;

InChIKey : PAVKBQLPQCDVNI-UHFFFAOYSA-N;

CAS number : 72238-02-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 72238-02-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C25H32N4O;

Details

Origin ID

C73241;

UMLS CUI

C0084319;

Currated CISMeF NLP mapping
- n,n-diethyl-n'-(9-methoxy-5,11-dimethyl-6h-pyrido[4,3-b]carbazol-1-yl)propane-1,3-diamine [Substance BNPC]
- retelliptine [MeSH concept]
- retelliptine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- n,n-diethyl-n'-(9-methoxy-5,11-dimethyl-6h-pyrido[4,3-b]carbazol-1-yl)propane-1,3-diamine [Substance BNPC]
- retelliptine [MeSH concept]
- retelliptine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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