Etoprine - CISMeF

Preferred Label : Etoprine;

NCIt synonyms : Ethodichlorophen; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-ethylpyrimidine; DDEP;

NCIt definition : A lipophilic, diaminopyrimidine folate antagonist with potential antineoplastic activity. Etoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism. This may eventually result in a reduction of cellular growth and the induction of apoptosis. In addition, this agent inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble etoprine is capable of crossing the blood-brain barrier.;

UNII : 406PGU9KGI;

InChIKey : PXLPCZJACKUXGP-UHFFFAOYSA-N;

CAS number : 18588-57-3;

Molecule name : AI3-25008;

Chemical formula : C12H12Cl2N4;

NSC code : 3062;

Details

Origin ID

C73236;

UMLS CUI

C0059875;

Currated CISMeF NLP mapping
- etoprine [MeSH concept]
- etoprine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- etoprine [MeSH concept]
- etoprine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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