" /> Etoprine - CISMeF





Preferred Label : Etoprine;

NCIt synonyms : Ethodichlorophen; 2,4-Diamino-5-(3,4-dichlorophenyl)-6-ethylpyrimidine; DDEP;

NCIt definition : A lipophilic, diaminopyrimidine folate antagonist with potential antineoplastic activity. Etoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism. This may eventually result in a reduction of cellular growth and the induction of apoptosis. In addition, this agent inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble etoprine is capable of crossing the blood-brain barrier.;

UNII : 406PGU9KGI;

InChIKey : PXLPCZJACKUXGP-UHFFFAOYSA-N;

CAS number : 18588-57-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 18588-57-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AI3-25008;

Chemical formula : C12H12Cl2N4;

NSC code : 3062;

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16/05/2024


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