Preferred Label : Pumaprazole;
NCIt definition : An imidazo-pyridine derivative with reversibly binding acid pump antagonist (APA)
activity. Contrary to the mechanism of action of the proton pump inhibitors, which
need to be activated by acid within the parietal cell canaliculus and which covalently
react through the action of an active intermediate with the SH groups of the H /K
-ATPase proton pump, pumaprazole competes reversibly with potassium binding on the
extracytoplasmic face of the catalytic (alpha) subunit of the proton pump, immediately
interrupting the pump's activity and the parietal cell secretion of H ions into the
gastric lumen, the final step in gastric acid production.;
UNII : DK95Z519WL;
InChIKey : NZQTVUWEPPDOKK-UHFFFAOYSA-N;
CAS number : 158364-59-1;
Molecule name : BY841;
Chemical formula : C19H22N4O2;
Origin ID : C73221;
UMLS CUI : C2347718;
Semantic type(s)
- concept_is_in_subset
