Tafenoquine - CISMeF

Preferred Label : Tafenoquine;

NCIt definition : An orally bioavailable 8-aminoquinoline derivative, with antimalarial activity. Although the mechanism is not completely understood, upon administration, tafenoquine inhibits the parasitic enzyme heme polymerase in the blood stages of the parasites. This inhibits the conversion of the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Tafenoquine is active against all the stages of Plasmodium species and is also active against the pre-erythrocytic liver stages of the parasites. This prevents the development of the erythrocytic forms of the parasite which are responsible for relapses in P. vivax malaria.;

UNII : 262P8GS9L9;

InChIKey : LBHLFPGPEGDCJG-UHFFFAOYSA-N;

CAS number : 106635-80-7;

Chemical formula : C24H28F3N3O3;

Details

Origin ID

C73006;

UMLS CUI

C0903411;

Automatic exact mappings (from CISMeF team)
- Tafenoquine [ICD-11 Extension code]
- tafenoquine [ATC Code]
Currated CISMeF NLP mapping
- Tafenoquine (substance) [SNOMED CT concept]
- tafenoquine [MeSH concept]
- tafenoquine [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing tafenoquine (medicinal product) [SNOMED CT concept]
- Tafenoquine (substance) [SNOMED CT concept]
- tafenoquine [ATC Code]
- tafenoquine [MeSH concept]
- tafenoquine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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