NCIt definition : An orally bioavailable 8-aminoquinoline derivative, with antimalarial activity. Although
the mechanism is not completely understood, upon administration, tafenoquine inhibits
the parasitic enzyme heme polymerase in the blood stages of the parasites. This inhibits
the conversion of the toxic heme into non-toxic hemazoin, thereby resulting in the
accumulation of toxic heme within the parasite. Tafenoquine is active against all
the stages of Plasmodium species and is also active against the pre-erythrocytic liver
stages of the parasites. This prevents the development of the erythrocytic forms of
the parasite which are responsible for relapses in P. vivax malaria.;
UNII : 262P8GS9L9;
InChIKey : LBHLFPGPEGDCJG-UHFFFAOYSA-N;
CAS number : 106635-80-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 106635-80-7
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