Preferred Label : Artesunate;
NCIt synonyms : WR 256283; 4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy}butanoic
acid;
NCIt definition : A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin
with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic
activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated
heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered
radicals form, which have been shown to damage and kill parasitic organisms. Additionally,
in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent
manner. Artesunate has also been shown to stimulate cell differentiation, arrest the
cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis
through mitochondrial and caspase signaling pathways. Artemisinin is isolated from
the plant Artemisia annua.;
UNII : 60W3249T9M;
InChIKey : FIHJKUPKCHIPAT-AHIGJZGOSA-N;
CAS number : 88495-63-0;
Chemical formula : C19H28O8;
ChEBI ID : CHEBI:63918;
Origin ID : C73005;
UMLS CUI : C0052432;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
