Splenic Manifestation of Chronic Lymphocytic Leukemia

Preferred Label : Splenic Manifestation of Chronic Lymphocytic Leukemia;

NCIt synonyms : Splenic Manifestation of CLL;

NCIt definition : Infiltration of the spleen by chronic lymphocytic leukemia. It primarily involves the white pulp.;

Neoplastic status : Malignant;

Details

Origin ID

C7300;

UMLS CUI

C1336062;

Disease excludes abnormal cell
- Leukemic Plasma Cell [NCIt concept]
- Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell [NCIt concept]
Disease excludes normal cell origin
- Myeloid Cell [NCIt concept]
- Precursor B-Lymphoblast [NCIt concept]
Disease may have findings
- Fatigue [NCIt concept]
- Lymphadenopathy [NCIt concept]
Has associated anatomic sites
- Hematopoietic and Lymphatic System [NCIt concept]
- Spleen [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Acute Clinical Course [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Abnormal Lymphocyte [NCIt concept]
- Leukemic Cell [NCIt concept]
- Leukemic Lymphocyte [NCIt concept]
- Leukemic Small Lymphocyte with Clumped Chromatin [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic B-Lymphocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Lymphocyte [NCIt concept]
- Neoplastic Small Lymphocyte with Clumped Chromatin [NCIt concept]
disease_has_finding
- Malignant Cellular Infiltrate [NCIt concept]
- Splenomegaly [NCIt concept]
disease_has_molecular_abnormality
- Clonal Immunoglobulin Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Heavy Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement [NCIt concept]
- Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement [NCIt concept]
disease_has_normal_cell_origin
- B-Lymphocyte [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
- Lymphocyte [NCIt concept]
- Mature B-Lymphocyte [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic and Lymphoid Tissue [NCIt concept]
- Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
- Lymphatic System [NCIt concept]
disease_mapped_to_chromosome
- Human Chromosome 11 [NCIt concept]
- Human Chromosome 12 [NCIt concept]
- Human Chromosome 13 [NCIt concept]
- Human Chromosome 17 [NCIt concept]
- Human Chromosome 6 [NCIt concept]
disease_mapped_to_gene
- BCL3 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Gain of Chromosome 12q13 [NCIt concept]
- Trisomy 12 [NCIt concept]
- del(11q22q23) [NCIt concept]
- del(13q14) [NCIt concept]
- del(17p13) [NCIt concept]
- del(6q21) [NCIt concept]
pathogenesis_of_disease_involves_gene
- BCL3 Gene [NCIt concept]
- BCL3 wt Allele [NCIt concept]

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