Trandolaprilat

Preferred Label : Trandolaprilat;

NCIt definition : A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.;

UNII : RR6866VL0O;

InChIKey : AHYHTSYNOHNUSH-HXFGRODQSA-N;

CAS number : 87679-71-8;

Chemical formula : C22H30N2O5;

Details

Origin ID

C72913;

UMLS CUI

C0165477;

Currated CISMeF NLP mapping
- trandolaprilat [MeSH concept]
- trandolaprilat [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- trandolaprilat [MeSH Supplementary Concept]
- trandolaprilat [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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